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Pharmaceuticals and Cosmetics

Application notes

TI0857

LC-MS: Taxifolin

TI0842

LC-MS: Antipsychotics

TI0841

LC-MS: Antipsychotics

TI0838

Antibiotic (vancomycin)

TI0836

LC-MS: antimigraines (selective serotonin agonists)

TI0835

LC-MS: antimigraines (selective serotonin agonists)

TI0833

Paraben isomers

TI0832

LC-MS: antimigraines (selective serotonin agonists)

TI0828

LC-MS: Basic compound (mobile phase pH)

TI0827

LC-MS: Alkaloids (alkali conditions)

TI0826

Tricyclic antidepressants

TI0729

The Unison UK-Phenyl column effectively separates fluoroamphetamine and fluoromethamphetamine isomers with identical mass.

TI0728

The Unison UK-Phenyl column is effectively able to separate triazolam and etizolam, which are very similar in structure.

TI0709

The Cadenza CD-C18 HT 3 micron column shows comparable resolution to a sub-2 micron column, with much lower pressure.

TI0708

The Cadenza CD-C18 HT 3 micron column shows better resolution between isopropylparaben and propylparaben than a sub-2 micron column, and the CD-C18 HT column also shows a higher plate count.

TI0707

The Cadenza CD-C18 HT 3 micron column shows lower pressure, higher plate count, and higher resolution than a sub-2 micron column.

TI0706

Tadalafil, Sildenafil, and Vardenafil are all polar small molecules that are easily separated on the Unison UK-C18 HT column. Not only are the slight structural differences between Sildenafil and Vardenafil recognized by the column, but it also separates all three compounds within 1.5 minutes.

TI0701

The Scherzo SM-C18 and the Scherzo SW-C18 show similar retention of these small molecules as the standard Unison UK-C18. However, the Scherzo SS-C18 shows the best resolution between these three compounds.

TI0690

Both Scherzo SM-C18 and Scherzo SW-C18 can separate an acidic compound (Ibuprofen) and a basic compound (Chlorpheniramine) at the same time. Scherzo SW-C18 works better under gradient elution, whereas Scherzo SM-C18 works better under isocratic elution.

TI0689

All of the columns listed can recognize the structural difference between these two isomers, and resolve them into two separate peaks.

TI0686

Both Presto FF-C18 and Intrada WP-RP can elute this large protein. Intrada WP-RP shows sharper peaks, meaning it can better recognize its structural components than Presto FF-C18.

TI0679

Acetaminophen and metabolite

TI0678

Acetaminophen and metabolite

TI0676

Ultra-high throughput LC-MS/MS analysis of drugs in blood plasma

TI0672

Basic pharmaceutical compounds

TI0669

Catecholamines

TI0662

Penicillin Antibiotics

TI0658

LC-MS/MS analysis of chloramphenicol (CP)

TI0656

LC-MS/MS analysis of clenbuterol (CBR)

TI0655

LC/MS analysis of nitrofurans metabolites (AOZ, AMOZ, AHD)

TI0640

Cold medicine compounds

TI0639

Cold medicine compounds

TI0628

Coumarins

TI0621

Plerixafor (Chemokine receptor antagonist)

TI0610

Zinc Pyrithione, Copper Pyrithione

TI0609

Cations

TI0604

Biodegradable polymer ( poly (DL-lactide) and poly (DL-lactide-co-glycolide) )

TI0603

Biodegradable polymer ( poly (DL-lactide) and poly (DL-lactide-co-glycolide) )

TI0602

Biodegradable polymer ( poly (DL-lactide) and poly (DL-lactide-co-glycolide) )

TI0593

Plerixafor (Chemokine receptor antagonist)

TI0592

Cetirizine (Antihistamine)

TI0545

Anti-hyperlipidemic drug in bovine serum (probucol)

TI0544

Benzathonium chloride

TI0543

Benzalkonium chloride

TI0537

Aminoglycoside antibiotics

TI0536

Methimazole and potential metabolites

TI0535

Nojirimycin relative compounds

TI0534

Hydroxyzine pamoate

TI0533

Clemastine fumarate

TI0532

Tipepidine hibenzate

TI0531

Chlorpheniramine maleate

TI0525

Basic compounds: Antidepressant drugs

TI0520

Sodium Chloride

TI0511

Zanamivir (Anti-flu medicine)

TI0510

Oseltamivir phosphate (Anti-flu medicine)

TI0509

Paroxetine HCl (Antidepressant)

TI0508

Rilmazafone HCl (Benzodiazepine hypnotic)

TI0507

Zopiclone (Nonbenzodiazepine hypnotic)

TI0506

Codeine phosphate (Narcotic antitussive)

TI0502

The Scherzo SM-C18 column shows excellent batch to batch reproducibility for anionic, cationic, and neutral compounds.

TI0500

The Scherzo SM-C18 column shows excellent batch to batch reproducibility for these small polar molecules.

TI0499

Pranoprofen (Nonsteroid anti-inflammatory drug:NSAID)

TI0498

Naftopidil (alpha1-receptor blocker)

TI0497

Furosemide (Diuretic)

TI0496

Menatetrenone (Vitamin K)

TI0495

Mequitazine (Antihistamine)

TI0494

Betamethasone (Antihistamine:Adrenal corticosteroid)

TI0463

LC-MS/MS Application for Duloxetine and Ethyl Morphine in Whole Blood

TI0458

Aliphatic Amines

TI0450

Propranolol

TI0436

Antibiotic (Vancomycin)

TI0435

Antibiotic (Tylosin)

TI0434

Antibiotic (Rifampicin)

TI0432

Nojirimycin Relative Compounds

TI0431

Deoxynojirimycin, Glucose

TI0428

Antibiotic (Erythromycin)

TI0427

Polypeptide Antibiotic (2) - Polymyxin B

TI0426

Aminoglycoside Antibiotics

TI0422

Acyclovir and Lactose

TI0417

Xanthines and Metabolites

TI0415

Xanthines and Metabolites

TI0411

LC-MS/MS Application -Tetracycline Antibiotics

TI0410

Tetracycline antibiotics

TI0409

5-Fluorouracil and Related Compounds

TI0403

Antioxidants

TI0402

Voglibose, Acarbose

TI0399

Polypeptide Antibiotic, bacitracin

TI0398

Basic Compounds: Antidepressant drug

TI0395

Disopyramide in PVP Aqueous Solution

TI0392

The Cadenza HS-C18 column shows excellent exclusion of the large polymer HPC from the main sharp peak, verapamil.

TI0391

Cefalexin in CMC-Na Aqueous Solution

TI0390

Lidocaine in CMC-Na Aqueous Solution

TI0389

Sulfamethoxazole in Alginate Aqueous Solution

TI0388

Calcitonin, salmon

TI0387

Calcitonin in Gelatin Aqueous Solution

TI0386

Indomethacin in gelatin aqueous solution

TI0372

Unison UK-Amino and Cadenza CD-C18 provide different selectivity for cephem antibiotics due to the difference in the stationary phase.

TI0365

Opiates of similar structure can be separated and analyzed by LC-MS. For example, morphine and oxymorphone are very similar but are resolved into two separate peaks.

TI0303

Minoxidil and metabolite

TI0288

Verapamil

TI0277

Morantel Citrate

TI0276

HT sulfonamides

TI0275

Aromatic boronic acids

TI0267

Anti-HIV nucleosides

TI0264

Parasympatholytics

TI0261

EDTA-Chelates

TI0258

Sulfonamides

TI0256

NSAIDs

TI0249

Ingrediants in eye drops (allantoin and chlorpheniramine, maleate)

TI0247

Separation properties of basic compounds on CL-C18

TI0246

Separation properties for acidic compounds on CL-C18

TI0229

Enrofloxacin

TI0224

Analysis of components of Shoseiryuto, an herbal medication, including paeoniflorin and ephedrine.

TI0223

Four synthetic antibacterial veterinary medications were separated using various columns. Using gradient elution and TFA modifier, the best separation was achieved using a phenyl and C8 phase.

TI0222

Analysis of the annular peptide antibiotic bacitracin using various reverse phase columns. Each column produces excellent peaks using gradient elution and TFA modifier.

TI0221

Analysis of the annular peptide antibiotic colistin, which targets the plasma membrane of gram negative bacteria, using various reverse phase columns. All columns achieve excellent separation of colistin isotomers using gradient elution and TFA modifier.

TI0220

Analysis of the macrolide antibiotic spiramycin using various reverse phase columns. Each column produces a sharp peak with TFA mobile phase.

TI0219

Analysis of the macrolide antibiotic erythromycin using various reverse phase columns. Each column produces a sharp peak at neutral pH.

TI0218

Analysis of salinomycin, a common antibiotic additive to animal feed. Note the incredible peak produced by the UK Phenyl column.

TI0217

Analysis of lasalocid, a common antibiotic additive to animal feed, in acid. Each column produces an excellent peak.

TI0216

Analysis of the antibiotic oxytetracycline, which impedes protein synthesis, using various reverse phase columns. Excellent peaks are produced by all columns in acidic conditions.

TI0215

Analysis of penicillin, which impedes synthesis of the bacterial cell wall, using various reverse phase columns. Under acidic conditions all columns produce excellent peaks.

TI0214

Reverse phase separation of the gram negative antibiotic lincomycin in acid produces an excellent peak.

TI0213

Analysis of the synthetic veterinary antibiotic thiamphenicol, which impedes protein synthesis, under neutral pH. The C18, C8 and Phenyl columns all produce excellent peaks.

TI0212

Analysis of the anthelminthic veterinary drug levamisol. Our reverse phase column with superior end-capping produces excellent peaks under neutral conditions.

TI0211

Analysis of the veterinary antimicrobrial oxolinic acid produces excellent peaks with various reverse phase columns.

TI0210

Analysis of nifurstyreneate monosodium salt, a veterinary antimicrobial nitrofuran used on fish, using various reverse phase columns.

TI0209

The reverse phase separation of the hydrophillic organic solvent dimethyl sulfoxide (DMSO) is difficult. However, our silica columns make a nonaqueous normal phase separation possible.

TI0206

25fg of the calcium antagonist diltiazem HCl can be quantitated by utilizing our 3um C8 column and a sensitive LC-MS/MS detector.

TI0205

2.5pg of the disinfectant chlorhexidine are measured with an LC-MS/MS analysis using our 3um C8 column.

TI0201

Analysis of 6 non-steroidal anti-inflammatory drugs under standard LC-MS conditions.

TI0200

The effect of electrostatic interaction on retention. Hydrophobic interaction, which depends on hydrogen bonding capacity and dipole-dipole interaction, affects the retention time of analysis on different columns.

TI0199

Separation of synephrine, found in the fruit of the Sour Orange Tree, and and octopamine, which operates on the sympathetic nervous system.

TI0196

Separation of the cardiac agent digitalis glycoside and its aglycon.

TI0186

Loading capacity of our versatile 20mm column is demonstrated at the laboratory level.

TI0183

Simultaneous analysis of compounds involved in the synthesis of andrenal corticosteroids.

TI0182

Separation of the structurally similar antifungal drugs econazole and miconazole.

TI0176

Reverse phase separation of the highly polar compounds uracil and fluorouracil, which is an anti-cancer drug.

TI0173

 

TI0165

Analysis of antipyretic analgesics.

TI0161

Analysis of an antioxidant food additives.

TI0142

Separation of isomers of the polymerization inhibitor hydroquinine.

TI0085

High throughput LC-MS analysis of local anasthetic and anti-arrhythmic drugs.

TI0080

Our 5um US-C18 delivers a satisfactory peak in the separation of anti-allergy medication at neutral pH.

TI0079

High-speed analysis of basic anti-allergy medications with 3um UK-C18 column at neutral pH

TI0078

3um UK-Phenyl delivers a sharp peak in high-speed mobile phase analysis at neutral pH

TI0077

3um UK-C8 delivers a sharp peak in high-speed mobile phase analysis at neutral pH

TI0072

Phenyl's high-speed analysis of basic vascular medications.

TI0059

Cadenza delivers satisfactory peak form for difficult to separate antibiotics.

TI0045

Comparison of peaks in the separation of fullerenes.

TI0044

Highly sensitive analysis of fullerenes and higher fullerenes with semi-micro columns.

TI0016

High speed separation of components of cold medication, with low solvent use.

TI0011

Cadenza CD C18, at half the length of conventional 5um ODS columns, can deliver even better high speed separation.

TI0010

Cadenza CD-C18 offers higher separation efficiency for basic compounds than possible with conventional columns.

TI0009

High speed LC-MS separation of nivaldopine and nisoldipine at half the length of conventional columns.

SP0028

An Evaluation of a Multi-Mode Stationary Phase for HPLC Separations Using a Multi-Component Test Mix

SP0026

Evaluation of Column Retentivity with large injection volume for high sensitive and High-Throughput LC-MS/MS Quantitative Analysis

SP0024

A simple and reliable method for simultaneous quantification of antiepileptic drugs in plasma using LC-MS/MS combined with direct injection column

SP0023

Development of a novel amino acids analysis column for LC-MS without derivatization

SP0020

A Novel Separation for Ethyl Glucuronide and Ethyl Sulfate using a Multi - Mode Reversed - Phase Column

SP0014

High Throughput Simultaneous Analysis of Immunosuppressants by ESI/ESI Dual Source Coaxial Flow Ion Source LC-MS/MS System

JA0018

Global proteomics and metabolomics in cancer biomarker discovery