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For Automated MALDI Matrix Deposition

The TM-Sprayer Tissue MALDI Sample Preparation System is designed to provide the highest quality matrix deposition on the two-dimensional biological samples, and can be integrated with any MALDI Mass Spectrometer platform.

TM Sprayer

The principle of MALDI MS is based on the introduction of a UV-activated matrix molecule in the immediate proximity of the analyte, so it is imperative to control the process by which matrix is introduced in the sample.  Unique in design, the TM-Sprayer provides heat to the matrix solution to accelerate adsorption into the tissue, as well as a controlled flow of dry air or nitrogen to focus the spray and control drying time.

TM-Sprayer, a Unique Solution to the Matrix Deposition Challenge

Using the TM-Sprayer the matrix solution is both heated and pressurized, which gives the matrix spray several beneficial properties:

  • The heated matrix is able to better penetrate the tissue surface and reach analytes.
  • The faster rate of evaporation avoids the creation of large matrix crystals (often known to create hot spots).
  • The pressurized spray is very directional, ensuring a precise location of the matrix deposition.
  • The combined effect of the nozzle velocity and sheath gas flow (dry air or nitrogen can be used) allows for controlled drying speed.

Why choose the TM-sprayer?

  • The TM sprayer Allows for true walkaway automation
  • Heated Nebuliser for better co-crystallization
  • "Airbrush" quality spray
  • Spraying of a glass slide in 2-3 mins (single pass)
  • Simple software with Graphic user interface
  • Supports wide range of standard and custom targets
  • Automatic 90 degree rotation of spray pattern from pass to pass
  • Pass location offset function
  • Ability to customize path of the sprayer through patterns

For Technical notes notes and information about the TM sprayer click the links below:
Instrument: Overview
Technical note: TN-28 Plant Metaobolites
Technical note: TN-30 Whole Body Imaging
TM-Sprayer for Automated MALDI Matrix Deposition